Piroxicam for Muscle Pain: What You Need to Know

When you’re dealing with piroxicam, a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain and swelling. Also known as Feldene, it’s one of the older NSAIDs still prescribed for stubborn muscle pain, arthritis, and inflammation. But it’s not your typical over-the-counter painkiller. Piroxicam works by blocking enzymes that cause swelling and pain, making it effective for deep, persistent aches—like those from sports injuries, back strain, or chronic joint issues. But because it sticks around in your system longer than ibuprofen or naproxen, it also carries more risk.

People often turn to piroxicam, a long-acting NSAID. Also known as Feldene, it’s one of the older NSAIDs still prescribed for stubborn muscle pain, arthritis, and inflammation. for muscle pain because it lasts up to 24 hours with just one dose. That sounds convenient, right? But here’s the catch: the same long half-life that makes it useful also increases the chance of stomach ulcers, kidney damage, and high blood pressure. If you’re over 60, have kidney problems, or take blood thinners, piroxicam might not be the best pick. Many doctors now prefer shorter-acting NSAIDs like ibuprofen, a common over-the-counter anti-inflammatory. Also known as Advil, it’s widely used for acute pain and inflammation. or naproxen, a longer-lasting but safer NSAID option. Also known as Aleve, it’s often recommended for chronic conditions. because they’re easier to control and less likely to cause serious side effects over time.

What’s missing from most discussions is how piroxicam for muscle pain fits into real life. It’s not a quick fix for a sore shoulder after lifting boxes. It’s meant for ongoing inflammation—like tendonitis that won’t quit, or muscle spasms tied to arthritis. If your pain comes and goes, there are safer options. But if you’ve tried ice, rest, and basic painkillers and nothing helps, piroxicam might be worth discussing with your doctor—especially if you’re already managing another condition like osteoarthritis. Just don’t take it without knowing the risks. The posts below dig into exactly that: how piroxicam affects your kidneys, when it’s worth the trade-off, and what other treatments actually work better for muscle pain without the hidden dangers.