Bupropion (Wellbutrin): What You Need to Know

If you or someone you care about was prescribed bupropion — often sold as Wellbutrin or Zyban — you probably have questions. This guide gives clear, usable facts: what it treats, how it works, common side effects, safety warnings, and quick tips to use it wisely.

How Bupropion Works & Common Uses

Bupropion boosts dopamine and norepinephrine activity in the brain. That helps with low mood and motivation and reduces nicotine cravings. Doctors commonly prescribe it for major depressive disorder and for smoking cessation. It doesn’t usually cause the sexual side effects seen with many SSRIs, which is why some people switch to it.

It comes in several forms: immediate‑release (IR), sustained‑release (SR), and extended‑release (XL). Typical patterns: IR is taken multiple times per day, SR usually twice daily, and XL once a day. Your provider will pick the form and dose based on your needs.

Safety Tips, Side Effects & When to Call a Doctor

Common side effects include dry mouth, trouble sleeping, jitteriness, headache, and mild nausea. Most are manageable and often ease after a week or two. Serious but less common risks include seizures, especially at higher doses, and increased thoughts of suicide in young people under 25 during the first weeks of treatment.

Don't take bupropion if you have a seizure disorder, a current or past eating disorder (bulimia or anorexia), or if you’re suddenly stopping heavy alcohol or sedatives. Also avoid bupropion if you’ve used an MAOI within the last 14 days — that combo can be dangerous.

Mixing bupropion with other stimulants, certain antidepressants, or high amounts of alcohol raises risk. If you drink heavily or use drugs irregularly, tell your prescriber before starting.

Practical tips: take XL in the morning to cut insomnia risk; if you get jittery or anxious, talk to your doctor about dose timing or switching formulations. If you miss a dose, take it as soon as you remember but don’t double up. Never change or stop your dose suddenly without medical advice — stopping abruptly can cause withdrawal or mood changes.

Watch mood closely, especially in the first month. If you notice worsening depression, new suicidal thoughts, severe agitation, or seizures, get medical help right away. For pregnancy or breastfeeding, discuss risks and benefits with your clinician — data exist but choices depend on your situation.

Need a refill or thinking of buying online? Only use licensed pharmacies that require a valid prescription. Avoid dubious sites that promise prescriptions without a doctor review. If cost or access is a problem, ask your provider about patient assistance programs or generic bupropion options.

Bupropion helps many people feel better and quit smoking, but like any medicine it works best when used carefully. Talk openly with your clinician about side effects, other meds you take, and what goals you want from treatment.