Alprostadil — what it is and how to use it safely

Alprostadil is a medicine that relaxes blood vessels. For adults it’s most often used to treat erectile dysfunction when pills don’t work or aren’t an option. For newborns, doctors sometimes use a different form of alprostadil to keep the ductus arteriosus open. If you were prescribed alprostadil, this page gives practical steps, common effects, and clear safety tips.

Forms, how they work, and what to expect

You’ll find two common forms for ED: an intracavernosal injection (direct into the penis) and a urethral suppository (MUSE). The injection usually produces an erection within 5–20 minutes. MUSE works in a similar window but often gives a milder response. Expect the erection to last from 30 minutes up to a few hours depending on dose and individual response. If you’re a parent of a newborn, the IV form used in hospitals helps control blood flow in critical situations — that will be managed by the neonatal team, not at home.

Storage matters. Most alprostadil products need refrigeration until first use. Follow the label — some pen kits or prepared syringes have different rules. Throw away anything past its expiry or that looks cloudy or discolored.

How to use it properly and reduce risks

If you get injections, a healthcare provider should show you the technique first. Clean the site, use the right syringe and needle, inject at the recommended spot on the side of the penis, and rotate injection sites. Never inject into the head of the penis. For MUSE, insert the tiny pellet into the urethra and hold the penis closed for a minute to keep the drug in place. Use the lowest effective dose. Write down doses and effects — that helps your prescriber adjust safely.

Watch for side effects: penile pain, minor bleeding, dizziness, and redness are common. A rare but serious problem is priapism — an erection lasting more than 4 hours. If that happens, get emergency care right away to avoid permanent damage. Also avoid using alprostadil if you have severe penile scarring, bleeding disorders, or certain heart problems without a doctor’s go-ahead.

Mixing meds needs care. Tell your doctor about blood thinners, nitrates, or other ED treatments. Don’t buy prescription alprostadil from unverified sites — counterfeit products can be unsafe or ineffective. Always confirm licenses and check reviews if you’re ordering online.

Final practical tip: expect a short learning curve. Many people need two or three supervised tries before using injections at home comfortably. Keep emergency contacts handy the first few times. If you have any troubling symptoms, call your provider — quick action prevents most complications.